# Chemistry and imaging on the NextSeq 1000/2000

The NextSeq 1000/2000 uses 2-channel chemistry, similar to the NextSeq 500/550, MiniSeq, and NovaSeq 6000. However, instead of using red and green channels, the NextSeq 1000/2000 uses blue and green. Using blue instead of red allows for greater resolution of tightly packed nano wells of the NextSeq 1000/2000 flow cells.

Figure 1: Representation of Standard chemistry dye by nucleotide.\
![](https://761066130-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FGM9W2DuBTgEXv1ClCm8H%2Fuploads%2Fgit-blob-729fc78e8e22f23faf9d2739a108b957fb5dc7f7%2Fimage1.jpg?alt=media)

Figure 2: Representation of NextSeq 1000/2000 XLEAP chemistry dye by nucleotide.\
![](https://761066130-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FGM9W2DuBTgEXv1ClCm8H%2Fuploads%2Fgit-blob-9a03dda04b18d983bba74661436f8899b93abe61%2Fimage2.jpg?alt=media)

\
\
\ <br>

|                                                                                                                                                                                                                                                                                                                                                                        |
| :--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------: |
| *For any feedback or questions regarding this article (Illumina Knowledge Article #3035), contact Illumina Technical Support* [*techsupport@illumina.com*](mailto:techsupport@illumina.com?subject=Question%2FFeedback%20Regarding%20Illumina%20Knowledge%20Article%20#000003035%20-%20Instrumentation%20\&body=Dear%20Illumina%20Technical%20Support,%0D%0A%0D%0A)*.* |