Troubleshooting no DRAGEN License after installing DRAGEN BCL Convert 4.2

• The upgrade of the NextSeq 1000/2000 Control Software (NCS) from version 1.5 to 1.7 requires the removal of previous DRAGEN workflow versions.

  • Only DRAGEN workflow version 4.2 and later are compatible with NCS v1.7

• It is normal when initializing the control software after updating to receive the notification: The active DRAGEN workflow is not compatible.

  • For instructions on how to un-install previous versions and install the correct DRAGEN workflow in response to this warning, see Knowledge Base Article: Troubleshooting DRAGEN version warnings and errors after the NextSeq 1000/2000 Control Software upgrade to version 1.7

After older DRAGEN version workflows have been deleted and the newer DRAGEN BCL convert 4.2 has been installed, in some cases the DRAGEN license will not populate. This can cause an error to display when trying to start a sequencing run.

To allow the DRAGEN license to display:

1. Login to ilmnadmin account on the instrument.

2. Download the DRAGEN BCL Convert workflow installer from Illumina's website: here

3. In the Control Software, Navigate to the menu > DRAGEN > Browse for New Version > Select the DRAGEN BCL Convert workflow installer

4. Follow the prompts to install this workflow and enter the ilmnadmin password when directed.

The DRAGEN license will now be displayed.

For any feedback or questions regarding this article (Illumina Knowledge Article #8923), contact Illumina Technical Support [e-mail].