# How to Power Cycle the MiSeq i100 Series

**Background**

The MiSeq i100 Series instruments may be power cycled safely when there are no sequencing runs or secondary analyses in progress. Software messages indicate when to shut down and restart the instrument to resolve an error or warning.

If the system does not shut down, contact [Illumina Technical Support](https://www.illumina.com/company/contact-us.html).

*Power Cycling the MiSeq i100 Series Instruments*

1. From the Control Software Home screen, select the **menu** icon in the upper-left corner.
2. Select **Shut down**.
3. When prompted, select **Yes, shut down instrument**.
4. Wait until the screen is powered off, then toggle the power switch on the **back-right** corner of the instrument to **OFF** (Figure 1).
5. Wait 1-2 minutes, then toggle the power switch on the **back-right** corner of the instrument to **ON**.
6. Wait until the power button on the front-right corner of the instrument illuminates, then press the **power button** to turn on the MiSeq i100 Series instrument (Figure 2).

![](https://761066130-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FGM9W2DuBTgEXv1ClCm8H%2Fuploads%2Fgit-blob-9b76afbb8cc08286151da64e00d868887c59b80e%2Fimage1.png?alt=media)

Figure 1 - Location of power switch

![](https://761066130-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FGM9W2DuBTgEXv1ClCm8H%2Fuploads%2Fgit-blob-3ae273f89a7d73384138e3f7a488e325cfa9cfed%2Fimage2.png?alt=media)

Figure 2 - Location of power button

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| *For any feedback or questions regarding this article (Illumina Knowledge Article #9277), contact Illumina Technical Support* [*techsupport@illumina.com*](mailto:techsupport@illumina.com?subject=Question%2FFeedback%20Regarding%20Illumina%20Knowledge%20Article%20#000009277%20-%20Instrumentation%20\&body=Dear%20Illumina%20Technical%20Support,%0D%0A%0D%0A)*.* |