Troubleshooting a Flow Cell Registration Failed (Skew) warning on the NextSeq 500/550

The following error message can occur during pre-run checks and is caused by a software communication issue and generally does not impact run performance.

The error states "Flow Cell Registration Failed (skew). No action necessary", as shown below.

Troubleshooting steps:

• Monitor run until completion and review run specifications.

  • If run does not meet specifications, contact Illumina Technical Support.

• Power cycle instrument before next run.

For further information, search for Knowledge Base articles Specifications for the NextSeq 500/550 and How to Perform a NextSeq 500/550 Power Cycle.

For any feedback or questions regarding this article (Illumina Knowledge Article #2053), contact Illumina Technical Support [email protected].