# Considerations for choosing an Illumina DNA PCR Free library preparation workflow
The Illumina DNA PCR-Free Library Prep, Tagmentation kit offers multiple workflows to accommodate variations in sample type, DNA input amount, and application. See the following table for considerations when choosing the optimal protocol. Always consult the [Reference Guide](https://support.illumina.com/downloads/illumina-dna-pcr-free-reference-guide.html) for full details, including validated catalog numbers.
**Equipment/consumables considerations**
\*Note: most instruments and sequencing consumables require additional custom sequencing primers. See the [Custom Primer Requirements for the Illumina DNA PCR-Free Prep, Tagmentation Kit](https://support.illumina.com/bulletins/2020/03/custom-primer-requirements-for-the-illumina-dna-pcr-free-library.html) bulletin for details.
**Quantification considerations**
\* ss Qubit = single-stranded Qubit reagents
\
\
\
| |
| :--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------: |
| *For any feedback or questions regarding this article (Illumina Knowledge Article #5264), contact Illumina Technical Support* [*techsupport@illumina.com*](mailto:techsupport@illumina.com?subject=Question%2FFeedback%20Regarding%20Illumina%20Knowledge%20Article%20#000005264%20-%20Library%20Preparation%20\&body=Dear%20Illumina%20Technical%20Support,%0D%0A%0D%0A)*.* |
---
# Agent Instructions: Querying This Documentation
If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question.
Perform an HTTP GET request on the current page URL with the `ask` query parameter:
```
GET https://knowledge.illumina.com/library-preparation/dna-library-prep/library-preparation-dna-library-prep-reference_material-list/000005264.md?ask=
```
The question should be specific, self-contained, and written in natural language.
The response will contain a direct answer to the question and relevant excerpts and sources from the documentation.
Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.