How to resolve 'An unexpected error has occurred with system integration' during initialization on the NovaSeq X Series Instruments

Background

Issues with the NovaSeq X Series Control Software connecting to the onboard Compute Engine (CE) result in a Critical System Error during initialization.

Critical system error: An unexpected error has occurred with system integration. Power cycle the instrument per system guide instructions and retry. If the issue persists, please contact Illumina Technical Support.

Troubleshooting Actions

1. Contrary to the error statement, do not power cycle the instrument.

2. Exit the NovaSeq X Series Control Software and wait 5 minutes, then restart the NovaSeq X Series Control Software.

3. If the issue persists, power cycle the instrument.

   1. For power cycling instructions, see Knowledge Article How to Power Cycle the NovaSeq X Series Instruments for details.

4. After logging into the Linux Operating System (OS), wait at least 10 minutes before starting the Control Software.

5. If the issue persists after power cycling, contact Illumina Technical Support.

For any feedback or questions regarding this article (Illumina Knowledge Article #7766), contact Illumina Technical Support [e-mail].