Troubleshooting Invalid Role Errors after Post Run Washes on the MiSeq

Users may encounter an error stating "Invalid Role" after completing a post-run wash on their MiSeq. This error prevents users from navigating back to the Home screen within the MiSeq Control Software (MCS)

This error may occur due to a transient communications error onboard the instrument or be the result of a required password update for Local Run Manager manifesting within MCS. In order to troubleshoot this error:

1. Exit MCS. This may require force-close the software through the Task Manager.

   1. Press Control + Alt + Delete

   2. Select Task Manager

   3. Select MiSeq Control Software and select End Task.

2. Use Chromium to open Local Run Manager. If a password update is required, this will automatically be indicated upon logging into Local Run Manager. More information can be found in the Knowledge Base Article Unlocking an account or resetting the password on Local Run Manager version 4

3. Once the password is updated (or if login has been successful), power cycle the instrument.

   1. For power cycling instructions, please refer to the Knowledge Base Article How to shut down or power cycle the MiSeq

If the error persists after power cycling the instrument, contact Illumina Technical Support.

For any feedback or questions regarding this article (Illumina Knowledge Article #9173), contact Illumina Technical Support [e-mail].