# Can DNA fusion calling be performed with TruSight Oncology 500 (TSO500) Tissue data?

**Are the TruSight Oncology 500 (TSO500) ctDNA probes for DNA fusion also included in the TSO500 Tissue (Solid) workflow? Can DNA fusion calling be enabled for TSO500 tissue samples?**

Both the TSO500 Tissue/Solid and TSO500 ctDNA workflows use the same DNA probe set, though the pipeline for TSO500 tissue samples is not configured nor optimized for DNA fusion calling.

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| *For any feedback or questions regarding this article (Illumina Knowledge Article #2972), contact Illumina Technical Support* [*techsupport@illumina.com*](mailto:techsupport@illumina.com?subject=Question%2FFeedback%20Regarding%20Illumina%20Knowledge%20Article%20#000002972%20-%20Library%20Preparation%20\&body=Dear%20Illumina%20Technical%20Support,%0D%0A%0D%0A)*.* |


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