> For the complete documentation index, see [llms.txt](https://knowledge.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://knowledge.illumina.com/microarray/general/microarray-general-faq-list/000009625.md).

# Are tip guides required for Tecan/IAPS with ILASS?

The Tecan/Infinium Automated Pipetting System (IAPS) with Illumina Automation Control (IAC) software is used to perform automated Infinium workflow for legacy Infinium BeadChip formats such as Infinium HD, HTS, LCG, and XT. The Tecan/IAPS with IAC uses Illumina Teflon tips and requires tip guides that are placed on top of the BeadChip to dispense samples properly during the Hybridization step.

The Tecan/Infinium Automated Pipetting System (IAPS) with Illumina Lab Automation Software Solution (ILASS) is used to perform automated Infinium workflow for Infinium EX Genotyping and EX Methylation formats, and select legacy Infinium formats (HD Methylation, LCG-8, LCG-PGx). The Tecan/IAPS with ILASS uses Tecan fixed tips and does not use tip guides for BeadChip sample hybridization.

| **Instrument and software** | **Compatible BeadChip formats**                                                       | **LiHa Tip type**    | **Tip guide** |
| --------------------------- | ------------------------------------------------------------------------------------- | -------------------- | ------------- |
| Tecan/IAPS with **IAC**     | HD (Ultra, Super, Methylation), HTS, LCG (8-sample, Quad), XT                         | Illumina Teflon tips | Required      |
| Tecan/IAPS with **ILASS**   | EX-24 and EX-48 (Genotyping, PGx, Methylation), HD Methylation, LCG\* (8-sample, PGx) | Tecan fixed tips     | Not used      |

\*A Quick Start Protocol for LCG semi-automated workflow is available for ILASS v1.6. Contact <techsupport@illumina.com> for more information.

For additional information, see the following:

* [Infinium LiHa and Infinium RoMA Operating Manual](https://support.illumina.com/downloads/infinium-liha-infinium-roma-manual-1000000110155.html)
* [Infinium RoMA (IAPS with ILASS) Product Documentation](https://support.illumina.com/downloads/infinium-roma-product-documentation.html)
* [Illumina Automation Control Release Notes](https://support.illumina.com/downloads/illumina-automation-control-release-notes.html)
* [ILASS Infinium Module Release Notes](https://support.illumina.com/downloads/ilass-release-notes.html)

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| *For any feedback or questions regarding this article (Illumina Knowledge Article #9625), contact Illumina Technical Support* [*techsupport@illumina.com*](mailto:techsupport@illumina.com?subject=Question%2FFeedback%20Regarding%20Illumina%20Knowledge%20Article%20#000009625%20-%20Microarray%20\&body=Dear%20Illumina%20Technical%20Support,%0D%0A%0D%0A)*.* |


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