# Can Local Run Manager be used to plan iSeq 100 runs with custom sequencing primers?

No, these runs must be set up in **Manual mode** within the iSeq 100 Control Software. Additionally, custom sequencing primers must be enabled within the control software by navigating to the control software menu and selecting **System Settings** > **Customization** > **Enable Custom Primers**.

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| *For any feedback or questions regarding this article (Illumina Knowledge Article #6500), contact Illumina Technical Support* [*techsupport@illumina.com*](mailto:techsupport@illumina.com?subject=Question%2FFeedback%20Regarding%20Illumina%20Knowledge%20Article%20#000006500%20-%20Instrumentation%20\&body=Dear%20Illumina%20Technical%20Support,%0D%0A%0D%0A)*.* |


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