> For the complete documentation index, see [llms.txt](https://knowledge.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://knowledge.illumina.com/software/on-premises-software/software-on-premises-software-troubleshooting-list/000008609.md).

# DRAGEN TSO500 ctDNA v2.1.1 install fails or breaks existing DRAGEN TSO500 installation

Installation of DRAGEN TruSight Oncology 500 (TSO500) ctDNA 2.1.1 can result in a Docker error.

If the following error presents during installation, follow the instruction below to fix the issue.

**Error downloading packages:**

**docker-ce-rootless-extras-20.10.22-3.el7.x86\_64: \[Errno 256] No more mirrors to try.**

**containerd.io-1.6.15-3.1.el7.x86\_64: \[Errno 256] No more mirrors to try.**

To fix this, run the following command.

yum remove -y docker-ce docker-ce-cli containerd.io docker-buildx-plugin docker-compose-plugin && yum clean all

Then run the ctdna installer.

TMPDIR=/staging /staging/install\_DRAGEN\_TruSight\_Oncology\_500\_ctDNA-2.1.1.run

Optionally, check the installation using the self-test script (/usr/local/bin/test\_DRAGEN\_TruSight\_Oncology\_500\_ctDNA-2.1.1.sh) included with [the product](https://support-docs.illumina.com/SW/DRAGEN_TSO500_ctDNA_v2.1/Content/SW/Apps/Install-Intro_appT500ctDNAlocal.htm).

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| *For any feedback or questions regarding this article (Illumina Knowledge Article #8609), contact Illumina Technical Support* [*techsupport@illumina.com*](mailto:techsupport@illumina.com?subject=Question%2FFeedback%20Regarding%20Illumina%20Knowledge%20Article%20#000008609%20-%20Software%20\&body=Dear%20Illumina%20Technical%20Support,%0D%0A%0D%0A)*.* |


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