# DRAGEN TSO500 ctDNA v2.1.1 install fails or breaks existing DRAGEN TSO500 installation Installation of DRAGEN TruSight Oncology 500 (TSO500) ctDNA 2.1.1 can result in a Docker error. If the following error presents during installation, follow the instruction below to fix the issue. **Error downloading packages:** **docker-ce-rootless-extras-20.10.22-3.el7.x86\_64: \[Errno 256] No more mirrors to try.** **containerd.io-1.6.15-3.1.el7.x86\_64: \[Errno 256] No more mirrors to try.** To fix this, run the following command. yum remove -y docker-ce docker-ce-cli containerd.io docker-buildx-plugin docker-compose-plugin && yum clean all Then run the ctdna installer. TMPDIR=/staging /staging/install\_DRAGEN\_TruSight\_Oncology\_500\_ctDNA-2.1.1.run Optionally, check the installation using the self-test script (/usr/local/bin/test\_DRAGEN\_TruSight\_Oncology\_500\_ctDNA-2.1.1.sh) included with [the product](https://support-docs.illumina.com/SW/DRAGEN_TSO500_ctDNA_v2.1/Content/SW/Apps/Install-Intro_appT500ctDNAlocal.htm). \ \ \
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