How to Replace a NextSeq 500/550 Air Filter

On newer versions of NextSeq 500/550 instruments and on older instruments receiving an air filter retrofit, the instrument will send a notification to change the air filter every 90 days. This can be replaced by the user and it is their responsibility to replace air filters due to being part of the maintenance.

NextSeq Air Filter Catalog #: 20063988

How to Change Air Filter

The instructions are also available in the NextSeq 500 and NextSeq 550 Sequencing System Guide

1. Remove air filter from package. Write date of install on frame.

2. On back of instrument, press down on top of filter tray. This will pop open.

3. Pull old filter out by grabbing top and sliding out.

4. Insert the new filter.

Note: The air filter can be inserted the wrong way. There are arrows pointing the correct direction and there is a warning sign present indicating it must not be visible this when inserted correctly.

1. Once new air filter has been inserted, close the filter tray and discard the old air filter.

For any feedback or questions regarding this article (Illumina Knowledge Article #5604), contact Illumina Technical Support [e-mail].