> For the complete documentation index, see [llms.txt](https://knowledge.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://knowledge.illumina.com/software/dragen/software-dragen-reference_material-list/000009848.md).

# Compatible callers for non human references in the DRAGEN Germline App

When analyzing non-human references with DRAGEN Germline v4.4, only a subset of variant callers is supported.

The following features are compatible with non-human analysis:

* SNV
* CNV
  * requires --cnv-bypass-contig-check=true as additional command line argument
  * Allele-specific CNV Calling option is not supported
* SV

The following features are incompatible with non-human analysis:

* Tandem Repeats Caller (STR, VNTR)
* Targeted Callers (cyp2d6, cyp21a2, gba, smn, hba, rh, lpa)
* HLA Typing
* Star Allele Caller
* Variant annotation
* QC Detect Contamination

Refer to the [DRAGEN Reference Support](https://help.dragen.illumina.com/product-guide/dragen-v4.4/dragen-reference-support#component-support) article for a full list of supported features.

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| *For any feedback or questions regarding this article (Illumina Knowledge Article #9848), contact Illumina Technical Support* [*techsupport@illumina.com*](mailto:techsupport@illumina.com?subject=Question%2FFeedback%20Regarding%20Illumina%20Knowledge%20Article%20#000009848%20-%20Software%20\&body=Dear%20Illumina%20Technical%20Support,%0D%0A%0D%0A)*.* |


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