What Tecan/Illumina instrument and software combinations require the use of Tip Guides?

The Tecan/Infinium Automated Pipetting System (IAPS) with Illumina Lab Automation Software Solution (ILASS) is used to perform automated Infinium workflow for Infinium EX Genotyping and EX Methylation formats, as well as selected legacy Infinium formats (HD Methylation, LCG-8, LCG-PGx). The Tecan/IAPS with ILASS uses Tecan fixed tips and does not use tip guides for BeadChip sample hybridization.

The Tecan/Infinium Automated Pipetting System (IAPS) with Illumina Automation Control (IAC) software is used to perform automated Infinium workflow for legacy Infinium BeadChip formats such as Infinium HD, HTS, LCG, and XT. The Tecan/IAPS with IAC uses Illumina Teflon tips and requires tip guides that are placed on top of the BeadChip to dispense samples properly during the Hybridization step.

Table1. Overview of the compatible BeadChip formats, LiHa Tip types and Tip Guide requirement on both systems.

Instrument and software	Compatible BeadChip formats	LiHa Tip type	Tip guide
Tecan/IAPS with IAC	HD (Ultra, Super, Methylation), HTS, LCG (8-sample, Quad), XT	Illumina Teflon tips	Required
Tecan/IAPS with ILASS	EX-24 and EX-48 (Genotyping, PGx, Methylation), HD Methylation, LCG* (8-sample, PGx)	Tecan fixed tips	Not used

* LCG-8 samples enabled on ILASS v1.6 only (Note: ILASS v1.6 does not support Clarity LIMS integration). A Quick Start Protocol for LCG semi-automated workflow is available for ILASS v1.6. Contact [e-mail] for more information.

For additional information, see the following:

• Infinium LiHa and Infinium RoMA Operating Manual

• Infinium RoMA (IAPS with ILASS) Product Documentation

• Illumina Automation Control Release Notes

• ILASS Infinium Module Release Notes

For any feedback or questions regarding this article (Illumina Knowledge Article #9625), contact Illumina Technical Support [e-mail].