# Air filter replacement on the NextSeq 1000/2000

The air filter is a single-use rectangular cartridge that covers the fan on the right side of NextSeq 1000/2000 instruments. It allows for proper cooling and prevents debris from entering the system. The instrument ships with one air filter installed and one spare. Additional air filters are included with an active instrument service contract but are not sent automatically; instead, users may request them by emailing Illumina Technical Support (<techsupport@illumina.com>), or they may be purchased separately from Illumina.

NextSeq 1000/2000 air filter catalog numbers:

* NextSeq 1000/2000 Air Filter Quantity 1: 20115807
* NextSeq 1000/2000 Air Filter Quantity 2: 20115806

Use the following instructions to replace an expired air filter every 6 months.

**Replacing the Air Filter**

1. On the top of the instrument, press the right side of the top panel to disengage, as shown in the following illustration.\
   ![](/files/SheSND5slWAOYH1GqxfC)
2. Open the panel.\
   ![](/files/VG0AdGUgfmCVJNQVSB49)
3. Press to release the air filter cartridge, remove it from the center of the panel, and discard it.\
   ![](/files/XjQwid1UvIQ7hf9MuDGR)
4. Insert a new air filter into the receptacle, and press to secure.\
   ![](/files/VAGUitGWsBYjtgpOaAum)
5. Close the top panel and press it into place.

Please, also refer to the Maintenance Section of the [NextSeq 1000 and 2000 Sequencing System Guide](https://support-docs.illumina.com/IN/NextSeq10002000/Content/IN/FrontPages/NextSeq10002000.htm).

This information is also available in video form: [How To Replace the NextSeq 1000/2000 Air Filter Video](/instrumentation/nextseq-1000-2000/instrumentation-nextseq-1000-2000-reference_material-list/000005622.md).

\
\
\ <br>

|                                                                                                                                                                                                                                                                                                                                                                        |
| :--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------: |
| *For any feedback or questions regarding this article (Illumina Knowledge Article #5457), contact Illumina Technical Support* [*techsupport@illumina.com*](mailto:techsupport@illumina.com?subject=Question%2FFeedback%20Regarding%20Illumina%20Knowledge%20Article%20#000005622%20-%20Instrumentation%20\&body=Dear%20Illumina%20Technical%20Support,%0D%0A%0D%0A)*.* |


---

# Agent Instructions: Querying This Documentation

If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question.

Perform an HTTP GET request on the current page URL with the `ask` query parameter:

```
GET https://knowledge.illumina.com/instrumentation/general/instrumentation-general-reference_material-list/000005457.md?ask=<question>
```

The question should be specific, self-contained, and written in natural language.
The response will contain a direct answer to the question and relevant excerpts and sources from the documentation.

Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.