> For the complete documentation index, see [llms.txt](https://knowledge.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://knowledge.illumina.com/instrumentation/general/instrumentation-general-reference_material-list/000003038.md).
# How to power cycle the NextSeq 1000/2000
**Background**
Power cycling the NextSeq 1000/2000 safely shuts down and restarts the system to restore a lost connection, align a specification, or resolve an initialization failure. Software messages indicate when to power cycle to resolve an error or warning. A complete power cycle will take 10 - 15 minutes to complete.
**To power cycle the instrument:**
1. From the control software menu, select **Shut Down Instrument**.
2. If the system does not shut down, hold the power button on the right side of the instrument until the lights fade.
3. When the power button pulses, press the power OFF (**Ο**) side of the toggle switch on the rear panel. The power button may continue to pulse after the power is turned off.
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4. Wait 30 seconds.
5. Press the power ON (**I**) side of the toggle switch.
6. When the power button pulses, wait 30 seconds and then press it.
* 
7. Wait about 5 minutes for the operating system to load. When the operating system is loaded, log on to the system. The control software launches and initializes the system. Wait about 5 minutes for the system initialization. The Home screen appears when initialization is complete.
This information is also available in video form. Search for Knowledge Base article [How To Power Cycle NextSeq 1000/2000 Video](/instrumentation/nextseq-1000-2000/instrumentation-nextseq-1000-2000-troubleshooting-list/000005552.md).
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| *For any feedback or questions regarding this article (Illumina Knowledge Article #3038), contact Illumina Technical Support* [*techsupport@illumina.com*](mailto:techsupport@illumina.com?subject=Question%2FFeedback%20Regarding%20Illumina%20Knowledge%20Article%20#000005552%20-%20Instrumentation%20\&body=Dear%20Illumina%20Technical%20Support,%0D%0A%0D%0A)*.* |
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